Primary Immune Regulatory Disorder (PIRD)
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Tailored care for primary immune regulatory disorder (PIRD)
Primary immune regulatory disorder (PIRD) is a name for a group of rare immune system disorders with a genetic cause. Symptoms of PIRD usually appear within the first few years of life and include hyperinflammation (overactive immune system), severe allergies and autoimmune conditions. PIRD can be difficult to treat.
Targeted PIRD testing and therapies
Children with PIRD have an immune system that may be overactive, underactive or doesn't respond as it should to challenges.
Many genetic mutations can lead to PIRD. Our specialists use genetic testing to determine the underlying cause of the condition. Once they have the right diagnosis, they design a treatment plan for your child that targets the immune system issue.
For example, a genetic test may show a defect in a gene that makes a specific protein that plays an important role in regulating the immune system. Our team can then treat the child with a drug that delivers this vital protein.
Stem cell transplant
For some patients, the best treatment is a stem cell transplant (also known as bone marrow transplant or BMT). In these cases, we partner with UCSF Health's renowned Pediatric BMT Program to provide seamless, comprehensive care.
Tailored care for primary immune regulatory disorder (PIRD)
Primary immune regulatory disorder (PIRD) is a name for a group of rare immune system disorders with a genetic cause. Symptoms of PIRD usually appear within the first few years of life and include hyperinflammation (overactive immune system), severe allergies and autoimmune conditions. PIRD can be difficult to treat.
Targeted PIRD testing and therapies
Children with PIRD have an immune system that may be overactive, underactive or doesn't respond as it should to challenges.
Many genetic mutations can lead to PIRD. Our specialists use genetic testing to determine the underlying cause of the condition. Once they have the right diagnosis, they design a treatment plan for your child that targets the immune system issue.
For example, a genetic test may show a defect in a gene that makes a specific protein that plays an important role in regulating the immune system. Our team can then treat the child with a drug that delivers this vital protein.
Stem cell transplant
For some patients, the best treatment is a stem cell transplant (also known as bone marrow transplant or BMT). In these cases, we partner with UCSF Health's renowned Pediatric BMT Program to provide seamless, comprehensive care.
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