49ers coach with aggressive myeloma gets new treatment at UCSF

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Written by John Doe — Medically reviewed by Jane Doe
Published August 13, 2025 — Reviewed August 14, 2025
5 min read
 

Johnny Holland has faced fierce foes for decades, first as a standout tackle in the National Football League, then as a beloved coach with the San Francisco 49ers. But when it comes to being poked by a nurse with a needle, the gridiron warrior shuts his eyes and scrunches his face.


"No matter how many shots I get, it always makes me jump," he said, grinning.
An inspirational role model to a legion of professional football players, Holland, 58, has an aggressive form of multiple myeloma – a blood cancer that develops in plasma cells, a type of white blood cell. For the last two years, he’s participated in a groundbreaking clinical study at UCSF Health, testing a combination of medications that have kept the cancer at bay.
Holland, who helps guide the 49ers defense as the team’s linebackers coach, is sharing his medical journey to raise awareness about the disease. Multiple myeloma, also called plasma cell myeloma, is among the most common blood cancers, with approximately 36,000 new cases diagnosed annually in the United States, according to the American Cancer Society.

Johnny's care team

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